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Title:
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Effect of the co-occurring components from olive oil and thyme extracts on the antioxidant status and its bioavailability in an acute ingestion in rats
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Author:
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Rubió Piqué, Laura; Serra Maqueda, Aida; Chen, O.; Macià i Puig, Ma Alba; Romero Fabregat, Mª Paz; Covas Planells, María Isabel; Solà, Rosa; Motilva Casado, Mª José
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Notes:
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The aim of this work was to examine whether bioactives in thyme could enhance the antioxidant capacity of phenolics in virgin olive oil and their bioavailability in Wistar rats. After acute oral administration of extracts from olive cake (OE), thyme (TE) or their combination (OTE), blood samples were collected from 0 to 360 min. Plasma antioxidant status was analyzed by DPPH and FRAP in plasma and by SOD, CAT and GPx activities in erythrocytes. Plasma pharmacokinetics of the main metabolites of bioactives in olive oil and thyme were characterized. Plasma non-enzymatic antioxidant capacity was significantly modulated by OE, TE, and OTE in a time-, assay, and extract-dependent manner. OE, TE, and OTE all significantly decreased superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity and catalase (CAT) activity was increased. Pharmacokinetic results showed that plasma concentration (Cmax) of the main olive phenolic metabolites in rats fed with OTE were similar to those of OE. These results indicate that an
enhanced bioavailability of olive phenolic compounds could occur in the presence of thyme, althoughany synergistic effect was observed in the antioxidant status when both phenolic extracts were administered. Antioxidant protection by phenolics from olive and thyme against oxidative stress occurs
primarily through a direct antioxidant effect and may be related to the phenolic plasmatic metabolites. |
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Subject(s):
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-Bioavailability
-olive oil phenols
-phenol metabolism
-thyme phenols
-antioxidant status
-Oli d'oliva
-Fenols
-Romaní
-Antioxidants
-Biodisponibilitat
-Olive oil
-Phenols
-Rosemary
-Antioxidants
-Bioavailability |
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Rights:
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(c) Royal Society of Chemistry (Gran Bretanya), 2014
info:eu-repo/semantics/restrictedAccess |
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Document type:
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Article
Article - Published version |
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Published by:
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Royal Society of Chemistry (Gran Bretanya)
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