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Title:
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MultitaskProtDB: a database of multitasking proteins
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Author:
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Hernández, Sergio; Ferragut, Gabriela; Amela, Isaac; Perez-Pons, Josep Antoni; Piñol, Jaume; Mozo Villarías, Angel; Cedano, Juan; Querol, Enrique
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Notes:
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We have compiled MultitaskProtDB, available online
at http://wallace.uab.es/multitask, to provide a repository
where the many multitasking proteins
found in the literature can be stored. Multitasking
or moonlighting is the capability of some proteins
to execute two or more biological functions.
Usually, multitasking proteins are experimentally
revealed by serendipity. This ability of proteins to
perform multitasking functions helps us to understand
one of the ways used by cells to perform
many complex functions with a limited number of
genes. Even so, the study of this phenomenon is
complex because, among other things, there is no
database of moonlighting proteins. The existence of
such a tool facilitates the collection and dissemination
of these important data. This work reports the
database, MultitaskProtDB, which is designed as a
friendly user web page containing >288 multitasking
proteins with their NCBI and UniProt accession
numbers, canonical and additional biological functions,
monomeric/oligomeric states, PDB codes
when available and bibliographic references. This
database also serves to gain insight into some characteristics
of multitasking proteins such as
frequencies of the different pairs of functions,
phylogenetic conservation and so forth.
Ministerio de Ciencia y Tecnología de Espanya [BIO2007-67904-C02-01, BFU2010-22209-C02-01]; Centre de Referència de R+D de Biotecnologia de la Generalitat de Catalunya; La Marató de TV3 [101930/31/32/33]; Comisión Coordinadora del Interior de Uruguay. The English of this manuscript has been corrected by Ms Lynn Strother. Funding for open access charge: [BIO2007-67904-C02-01 and BFU2010-22209-C02-01]. |
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Rights:
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cc-by, (c) Hernández et al., 2013
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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article
publishedVersion |
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Published by:
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Oxford University Press
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