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Title:
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Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
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Author:
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Naudí i Farré, Alba; Jové Font, Mariona; Ayala Jové, Ma. Victoria (Maria Victoria); Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Gonzalo Benito, Hugo; Boada Pallàs, Jordi; Prat Corominas, Joan; Portero Otín, Manuel; Pamplona Gras, Reinald
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Notes:
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Oxidative stress has been implicated in diabetes long-term complications. In this paper, we summarize the growing evidence
suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a
maladaptive response by affecting severalmetabolic and signaling pathways involved in the pathophysiology of cellular dysfunction
and diabetic complications. In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free
radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the
resulting maladaptive response that leads to a cellular dysfunction and pathological state. Finally, we outline potential therapies
for diabetes focused to the prevention of mitochondrial oxidative damage.
Investigations of the authors of this paper have been supported by Grants ref. BFI2003-01287, BFU2006-14495/BFI and BFU2009-11879/BFI; Reticef RD06/0013/0012, and 2005SGR00101, and 2009SGR735 from the Ministry of Science and Innovation, Ministry of Health, and the Autonomous Government of Catalonia, respectively. |
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Rights:
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cc-by (c) Naudí i Farré, Alba et al., 2012
http://creativecommons.org/licenses/by/3.0/es/
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Document type:
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article
publishedVersion |
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Published by:
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Hindawi Publishing Corporation
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