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Título:
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Comparative effects of beta2-adrenergic agonists on muscle waste associated with tumour growth.
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Autor/a:
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Carbó, Neus; López-Soriano, Francisco J.; Tarragó, Teresa; González, Olga; Llovera i Tomàs, Marta; López-Soriano, Joaquín; Argilés, Josep M.
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Notas:
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The implantation of the Yoshida AH- 130 ascites hepatoma (a fast growing tumour) to rats resulted in a drarnatic loss of both
white adipose tissue and muscle (skeletal and cardiac) mass. Administration of &adrenergic agonists to rumour-hearing rats
resulted in a partial recovery of skeletal muscle and heart mass. Treatment of the tumour-bearing animals with the different
drugs (salbutamol, salmeterol and clenbuterol) did not influence tumour growth or food intake so it can be suggested that the
effects were solely due to metabolic changes. In addition, while the three drugs had clear effects on gastrocnemius muscles,
clenbuterol and salbutamol had also an effect on soleus, and salbutamol had a clear effect on cardiac muscle. It is suggested
that any of the studied &adrenergic agonists (but perhaps, particularly salmeterol) could be used clinicany in the treatment of
cancer cachexia. |
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Materia(s):
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-Tumour growth
-Muscle waste
-β2 agonists |
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Derechos:
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(c) Elsevier Science Ireland Ltd., 1997
info:eu-repo/semantics/restrictedAccess |
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Elsevier
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Compartir:
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