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Título:
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Differential expression of LIM-Homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds
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Autor/a:
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Abellán Ródenas, Antonio; Menuet, Arnaud; Dehay, Colette; Medina Hernández, Loreta Mª; Rétaux, Sylvie
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Notas:
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Reelin-expressing Cajal-Retzius (CR) cells are among the earliest
generated cells in the mammalian cerebral cortex and are believed
to be crucial for both the development and the evolution of
a laminated pattern in the pallial wall of the telencephalon. LIMhomeodomain
(LIM-hd) transcription factors are expressed during
brain development in a highly restricted and combinatorial manner,
and they specify regional and cellular identity. We have investigated
the expression of the LIM-hd members Lhx1/Lhx2/Lhx5/
Lhx6/Lhx9 in the reelin-expressing cells, the pallium, and the
regions of origin of CR cells including the cortical hem of 3 amniote
species: the mouse, the chick, and the macaque monkey. We found
major differences in the combinatorial LIM-hd expression in the
marginal zone as well as in the hem. 1) Lhx5 is a ‘‘preferential LIMhd’’
for CR cells in mammals but not expressed by these cells in
chicks. 2) Lhx2 is expressed in the hem of the chick, whereas it is
excluded from this region in mouse. 3) Whereas mouse CR cells
express Lhx5/Lhx1, their monkey counterparts express 4 of these
factors: Lhx1/Lhx2/Lhx5/Lhx9. We discuss our findings in evolutionary
terms for the specification of the midline hem and CR cell type
and the emergence of the cortical lamination pattern.
This work was supported by Centre National de la Recherche Scientifique (CNRS), Agence Nationale pour la Recherche (ANR-Neuro [MIDLINE]) to S.R.; Agence Nationale pour la Recherche (ANR [06-NEUR-010-01]), SECO (EU FP7-216593) to C.D.; Spanish Ministry of Education and Science and FEDER (DGICYT-FEDER grant no. BFU2006-14804-C02-02/BFI) to L.M. A.M. was a postdoctoral fellow supported by CNRS. |
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Materia(s):
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-Cortex
-Evolution
-LIM code
-Pallium |
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Derechos:
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(c) Oxford Journals, 2009
info:eu-repo/semantics/restrictedAccess |
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Oxford Journals
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Compartir:
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