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We compared the combinatorial expression patterns of several
LIM domain-containing regulatory genes in the ventrolateral
pallium of mouse and chicken, in order to identify the
homologues of the ventral pallial amygdala and other olfactory
structures in birds. Lmo3, Lmo4, Lhx2, and Lhx9
showed comparable expression patterns in the telencephalon
of mouse and chicken, which allowed distinction of the
ventrolateral pallium and, particularly, the ventral pallial
amygdala and entorhinal cortex. Lmo3 was expressed in
most of the ventrolateral pallium in both species, including,
in chicken, the piriform cortex and dorsal ventricular ridge
(mesopallium, nidopallium, and arcopallium) and, in mouse,
the piriform cortex, most of the claustral complex, and the
pallial amygdala. Lhx9 was differentially expressed in the
ventral pallium, where it was restricted to its rostral (olfactory
bulb) and caudal (amygdalar and entorhinal) poles. In
the caudal pole, expression of Lhx9 overlapped that of its
paralog Lhx2. According to these expression patterns, the
chicken ventral pallial amygdala appears to include the caudal
dorsolateral pallium, the caudal nidopallium, and the
whole arcopallium, and each one relates to a distinct ventricular
sector. Finally, the combinatorial expression patterns
of Lmo3, Lhx9, and Lmo4 distinguished four distinct
subdivisions in the superficial, olfactorecipient area of the
chicken ventral pallium, which appear comparable to the
piriform, entorhinal, amygdalopiriform, and amygdalar cortices
of mammals. The results are discussed in the context
of the two existing, opposite views on the homology of the
dorsal ventricular ridge of sauropsids and in terms of the
evolution of pallial derivatives. J. Comp. Neurol. 516:
166–186, 2009.
Grant sponsor: Spanish Ministry of Education and Science and FEDER (DGICYT-FEDER); Grant number: BFI2003-06453-C02-02 (to L.M.); Grant number: BFU2006-14804-C02-02/BFI (to L.M.); Grant sponsor: ANR-Neuro (to S.R.); Grant sponsor: Spanish Ministry of Education and Science (to A.A.). |
