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Título:
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Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex
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Autor/a:
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Dávila, José Carlos; Real, M. Ángeles; Olmos, Luis; Legaz, Isabel; Medina Hernández, Loreta Mª; Guirado, Salvador
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Notas:
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We analyzed the development of immunoreactive expression patterns for the neurotransmitter
-aminobutyric acid (GABA) and the calcium-binding proteins calbindin, calretinin, and parvalbumin
in the embryonic and postnatal mouse claustral complex. Each calcium-binding protein shows a
different temporal and spatial pattern of development. Calbindin-positive cells start to be seen very
early during embryogenesis and increase dramatically until birth, thus becoming the most abundant
cell type during embryonic development, especially in the ventral pallial part of the claustrum. The
distribution of calbindin neurons throughout the claustrum during embryonic development partly
parallels that of GABA neurons, suggesting that at least part of the calbindin neurons of the claustral
complex are GABAergic and originate in the subpallium. Parvalbumin cells, on the other hand, start
to be seen only postnatally, and their number then increases while the density of calbindin neurons
decreases. Based on calretinin expression in axons, the core/shell compartments of the dorsal claustrum
start to be clearly seen at embryonic day 18.5 and may be related to the development of the
thalamoclaustral input. Comparison with the expression of Cadherin 8, a marker of the developing
dorsolateral claustrum, indicates that the core includes a central part of the dorsolateral claustrum,
whereas the shell includes a peripheral area of the dorsolateral claustrum, plus the adjacent ventromedial
claustrum. The present data on the spatiotemporal developmental patterns of several subtypes
of GABAergic neurons in the claustral complex may help for future studies on temporal lobe
epilepsies, which have been related to an alteration of the GABAergic activity.
Grant sponsor: Spanish Direccio´n General de Investigacio´n-Fondo Europeo de Desarrollo Regional (FEDER); Grant number: BFI2003-06453-C02-01/02; Grant sponsor: Fondo de Investigaciones Sanitarias-FEDER; Grant number: 01/0057-02; Grant sponsor: Se´neca; Grant number: PB/50/FS/02; Grant sponsor: Red Centro de Investigacio´n de Enfermedades Neurolo´gicas-Nodo 318. |
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Materia(s):
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-Calcium-binding proteins
-Dorsal claustrum
-Endopiriform nucleus
-Immunohistochemistry |
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Derechos:
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(c) Wiley-Liss, Inc. 2005
info:eu-repo/semantics/restrictedAccess |
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Wiley
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Compartir:
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