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Title:
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Metabolomics predicts neuroimaging characteristics of transient ischemic attack patients
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Author:
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Purroy Garcia, Francisco; Cambray Carner, Serafí; Mauri-Capdevila, Gerard; Jové Font, Mariona; Sanahuja Montesinos, Jordi; Farré, Joan; Benabdelhak Abbou, Ikram; Molina Seguin, Jessica; Colàs Campàs, Laura; Begué Gómez, Robert; Gil, M. Isabel; Pamplona Gras, Reinald; Portero Otín, Manuel
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Notes:
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Background: Neuroimaging is essential for the diagnosis and prognosis of transient ischemic attack (TIA). The discovery
of a plasmatic biomarker related to neuroimaging findings is of enormous interest because, despite its relevance,
magnetic resonance diffusionweighted imaging (DWI) is not always available in all hospitals that attend
to TIA patients.
Methods: Metabolomic analyses were performed by liquid chromatography coupled to mass spectrometry in
order to establish the metabolomic patterns of positive DWI, DWI patterns and acute ischemic lesion volumes.
We used these methods with an initial TIA cohort of 129 patients and validated them with a 2nd independent
cohort of 152 patients.
Findings: PositiveDWIwas observed in 115 (40.9%) subjects and scattered pearls in one arterial territory was the
most frequent lesion pattern (35.7%). The median acute ischemic lesion volume was 0.33 (0.15–1.90) cm3. We
detected a specific metabolomic profile common to both cohorts for positive DWI (11 molecules including creatinine,
threoninyl-threonine, N-acetyl-glucosamine, lyso phosphatidic acid and cholesterol-related molecules)
and ischemic lesion volume (10 molecules including lysophosphatidylcholine, hypoxanthine/threonate, and leucines).
Moreover lysophospholipids and creatinine clearly differed the subcortical DWI pattern from other patterns.
Interpretation: There are specific metabolomic profiles associated with representative neuroimaging features in
TIA patients. Our findings could allow the development of serum biomarkers related to acute ischemic lesions
and specific acute ischemic patterns.
This work has been supported by the Government of Catalonia-Agència de Gestió d'Ajuts Universitaris i de Recerca [2009SGR-735 and 2014SGR-1418], the Spanish Ministry of Health [FIS 11-02033, 14-001115 and 14-00328] and the Marató of TV3 Foundation [95/C/2011]. It was also supported by the European Regional Development Fund (PI 14/01115) “A way to build Europe”. |
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Subject(s):
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-Diffusion magnetic resonance imaging
-Metabolomics
-TIA |
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Rights:
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cc-by-nc-nd (c) Purroy et al., 2016
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Document type:
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article
publishedVersion |
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Published by:
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Elsevier
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