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Título:
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Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice
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Autor/a:
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Cicvaric, Ana; Yang, Jiaye; Bulat, Tanja; Zambon, Alice; Dominguez-Rodriguez, Manuel; Kühn, Rebekka; Sadowicz, Michael G.; Siwert, Anjana; Egea Navarro, Joaquim; Pollak, Daniela D.; Moeslinger, Thomas; Monje, Francisco J.
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Notas:
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The Fibronectin Leucine-Rich Transmembrane protein 2 (FLRT2) has been implicated in several hormone -and sex-dependent physiological and pathological processes (including chondrogenesis, menarche and breast cancer); is known to regulate developmental synapses formation, and is expressed in the hippocampus, a brain structure central for learning and memory. However, the role of FLRT2 in the adult hippocampus and its relevance in sex-dependent brain functions remains unknown. We here used adult single-allele FLRT2 knockout (FLRT2+/−) mice and behavioral, electrophysiological, and molecular/biological assays to examine the effects of FLRT2 haplodeficiency on synaptic plasticity and hippocampus-dependent learning and memory. Female and male FLRT2+/− mice presented morphological features (including body masses, brain shapes/weights, and brain macroscopic cytoarchitectonic organization), indistinguishable from their wild type counterparts. However, in vivo examinations unveiled enhanced hippocampus-dependent spatial memory recall in female FLRT2+/− animals, concomitant with augmented hippocampal synaptic plasticity and decreased levels of the glutamate transporter EAAT2 and beta estrogen receptors. In contrast, male FLRT2+/− animals exhibited deficient memory recall and decreased alpha estrogen receptor levels. These observations propose that FLRT2 can regulate memory functions in the adulthood in a sex-specific manner and might thus contribute to further research on the mechanisms linking sexual dimorphism and cognition.
FJM was supported by Siemens (Healthcare GmbH) and by the Austrian Science Fund (FWF: P27551). DDP is supported by the Austrian Science Fund (FWF): P27520, P28683, and W1205. |
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Derechos:
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cc-by (c) Cicvaric et al., 2018
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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article
publishedVersion |
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Editor:
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Nature Publishing Group
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