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Título:	Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity
Autor/a:	Cervera i Segura, Ricard, 1960-; Navarro López, Margarita; López-Soto, Alfonso; Cid Xutglà, M. Cinta; Font Franco, Josep, 1953-2006; Esparza Sánchez, Jordi; Reverter Calatayud, Juan Carlos; Monteagudo Terres, Juan; Ingelmo Morín, Miguel; Urbano Márquez, A. (Álvaro)
Otros autores:	Universitat de Barcelona
Abstract:	OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.
Materia(s):	-Malaltia de Behçet -Endoteli -Autoanticossos -Immunoglobulines -Behçet's disease -Endothelium -Autoantibodies -Immunoglobulins
Derechos:	(c) BMJ Publishing Group Ltd, 1994
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	BMJ Group
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