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Título: | Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension |
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Autor/a: | Teulon, Jean-Marie; Mahé, Nathalie; Do, Bernard; Nicolaï, Béatrice; Rietveld, Ivo B.; Barrio Casado, María del; Tamarit Mur, José Luis; Céolin, René; Ghéchot, Christophe |
Otros autores: | Universitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear; Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
Abstract: | Aging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference data beyond regulatory considerations. Tienoxolol was studied after 25 years of storage in the dark under ambient conditions. About 86% of the samples still consisted of tienoxolol and the main impurity (13%) was caused by the hydrolysis of the ester moiety. Protection from humidity is therefore important. Other sensitive groups containing nitrogen and sulfur appear to be quite stable with less than 0.8% conversion over 25 years. In addition, the crystal structure has been solved. Tienoxolol orange needles were found to crystallize in the orthorhombic non-centrosymmetric space group Iba2, indicating that the crystal is a racemic compound. The unit cell parameters at room temperature are a = 10.069(5)A˚ , b = 45.831(10)A˚ , and c = 9.822(5) ˚A and the unit cell volume is 4533(3) ˚A3 with Z = 8. © 2011 Elsevier B.V. |
Materia(s): | -Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia -Àrees temàtiques de la UPC::Física::Física de l'estat sòlid -Hypertension Age factors -X-ray diffractometer -Indústria farmacèutica -- Investigació -Física de l'estat sòlid |
Derechos: | Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento: | Artículo - Versión publicada Artículo |
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