In this paper the topic of Structural Reliability Analysis and its importance in modern Civil Engineering is introduced. Throughout the paper, some advantages that simulation-based approaches offer with respect to other classical approaches are discussed. After a review of the most relevant literature on the subject, a simulation-based approach is described. Our methodology makes use of discrete-event simulation techniques to help the civil engineer design more reliable and cost-efficient structures. A numerical example illustrates some potential applications of the proposed methodology. Finally, potential research and academic applications of this approach are also discussed.