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Título:
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Multisite recording of extracellular potentials produced by microchannel-confined neurons in-vitro
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Autor/a:
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Claverol Tinturé, Enrique; Cabestany Moncusí, Joan; Rosell Ferrer, Francisco Javier
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
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Abstract:
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Towards establishing electrical interfaces with patterned in vitro neurons, we have previously described the fabrication of hybrid elastomer-glass devices polymer-on-multielectrode array technology and obtained single-electrode recordings of extracellular potentials from confined neurons (Claverol-Tinturé et al., 2005). Here, we demonstrate the feasibility of spatially localized multisite recordings from individual microchannel-guided neurites extending from microwell-confined somas with good signal-to-noise ratios (20 dB) and spike magnitudes of up to 300 μV.
Single-cell current source density (scCSD) analysis of the spatio-temporal
patterns of membrane currents along individual processes is illustrated. |
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Abstract:
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Peer Reviewed |
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Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica
-Electrodiagnosis
-Membranes (Biology)
-Biolectric potentials
-Biomembranes
-BioMEMS
-Cellular biophysics
-Microelectrodes
-Neurophysiology
-Spatiotemporal phenomena
-Multisite recording
-Extracellular potentials
-Microchannel-confined neurons
-Electrical interfaces
-Patterned in vitro neurons
-Hybrid elastomer-glass. devices polimer-on-multielectrode array technology
-Single-electrode recordings
-Spatially localized multisite recordings
-Microchannel-guided neurites
-Microwell-confined somas
-Single-cell current source density
-Spatiotemporal patterns
-Membrane currents
-Electrodiagnòstic
-Membranes (Biologia) |
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Derechos:
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Tipo de documento:
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Artículo |
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Editor:
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IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
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Compartir:
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