This paper proposes a hybrid algorithm, combining Biased-Randomized (BR) processes with an Iterated Local Search (ILS) meta-heuristic, to solve the Multi-Depot Vehicle Routing Problem (MDVRP). Our approach assumes a scenario in which each depot has unlimited service capacity and in which all vehicles are identical (homogeneous fleet). During the routing process, however, each vehicle is assumed to have a limited capacity. Two BR processes are employed at different stages of the ILS procedure in order to: (a) define the perturbation operator, which generates new ‘assignment maps’ by associating customers to depots in a biased-random way –according to a distance-based criterion; and (b) generate ‘good’ routing solutions for each customers-depots assignment map. These biased-randomization processes rely on the use of a pseudo-geometric probability distribution. Our approach does not need from fine-tuning processes which usually are complex and time consuming. Some preliminary tests have been carried out already with encouraging results.