Title:
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An enantioselective entry to cis-perhydroisoquinolines
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Author:
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Amat Tusón, Mercedes; Pérez Bosch, Maria; Minaglia, Annamaria Tania; Casamitjana i Badia, Núria; Bosch Cartes, Joan
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Other authors:
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Universitat de Barcelona |
Abstract:
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An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. |
Subject(s):
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-Isoquinolina -Isoquinoline |
Rights:
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(c) American Chemical Society , 2005
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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