Título:
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Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta
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Autor/a:
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Liesa Torre-Marín, Montserrat; Borda d'Agua, Bárbara; Medina Gómez, Gema; Lelliott, Christopher J.; Paz, José Carlos; Rojo, Manuel; Palacín Prieto, Manuel; Vidal Puig, Antonio; Zorzano Olarte, Antonio
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Background There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. Methodology/Principal Findings Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1β is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1β increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1β-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1β increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor α (ERRα). Conclusions/Significance Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1β in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2. |
Materia(s):
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-Mitocondris -Regulació genètica -Mitochondria -Genetic regulation |
Derechos:
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cc-by (c) Liesa, M. et al., 2008
http://creativecommons.org/licenses/by/3.0/es |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science (PLoS)
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