Títol:
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Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
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Autor/a:
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Aso Pérez, Ester; Balerio, Graciela N.; Maldonado, Rafael, 1961-
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Abstract:
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Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: The present study was designed to examine the possible involvement of the cannabinoid system in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Methods: Animals were only exposed once to nicotine. The acute administration of low (0.05, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus-maze, i.e., anxiolytic- and anxiogenic-like responses, respectively. The effects of the pretreatment with the CB1 cannabinoid receptor antagonist, rimonabant (0.25, 0.5 and 1 mg/kg, ip), and the cannabinoid agonist, 9-tetrahydrocannabinol (0.1 mg/kg, ip), were evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. Results: Rimonabant completely abolished nicotine-induced anxiolytic-like effects and increased the anxiogenic-like responses of nicotine, suggesting an involvement of CB1 receptors in these behavioural responses. On the other hand, 9-tetrahydrocannabinol failed to modify nicotine anxiolytic-like responses, but attenuated its anxiogenic-like effects. In addition the association of non-effective doses of 9-tetrahydrocannabinol and nicotine produced clear anxiolytic-like responses. Conclusions: These results demonstrate that the endogenous cannabinoid system is involved in the regulation of nicotine anxiety-like behaviour in mice, and provide new findings to support the use of cannabinoid antagonists in the treatment of tobacco addiction. |
Abstract:
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This work has been supported by grants from National Institutes of Health (1R01-DA016768-0111), Ministerio de Educación y Ciencia (BFU 2004–00920/BFI), Marató TV3, Redes de Centros y Grupos del Instituto de Salud Carlos III (C03/06 and G03/005), Generalitat de Catalunya (2002 SGR00193) and the European Comission (Quality of Life and Management of Living Resources QLRT-2001-01691 LSHM-CT 2004-005166). Graciela Balerio is a post doctoral fellow supported by “Fundación Carolina”. |
Matèries:
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-Cannabinoides -- Receptors -Nicotina -- Efectes fisiològics -Nicotina -- Receptors -Cannabinoides -- Efectes fisiològics -Nicotine -Cannabinoid system -Elevated plus-maze -Anxiety |
Drets:
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(c) Springer. The original publication is available at www.springerlink.com
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Tipus de document:
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Article Article - Versió presentada |
Publicat per:
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Springer
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