Cannabinoid addiction: behavioral models and neural correlates

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Título:	Cannabinoid addiction: behavioral models and neural correlates
Autor/a:	Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando
Abstract:	The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid abuse have been developed only recently. We review these models and the role of the CB1 cannabinoid receptor, the main target of natural cannabinoids, and its interaction with opioid and dopamine transmission in reward circuits. Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000;Schlicker and Kathmann, 2001).
Abstract:	This work has been supported by grants from Plan Nacional Sobre Drogas, European Communities BIOM ED2 Grant PL 982267 and Fifth Framework Programme, Grant QLRT-2000-01691, Generalitat de Catalunya (Research Distinction), Human Frontier Science Program Organization (RG0077/2000-B), Ministerio de Ciencia y Tecnología (SAF 2000-0101), Fondo de Investigación Sanitaria (FIS 2001-00654), and Laboratorios Dr. Esteve.
Materia(s):	-Cannabinoides -- Efectes fisiològics -Cannabinoides -- Receptors -Drogoaddicció -- Aspectes moleculars
Derechos:	(c) 2002, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/22/9/3326
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Society for Neuroscience
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