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Títol:	Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
Autor/a:	Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas
Abstract:	The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic treatment with Delta9-tetrahydrocannabinol, the development of tolerance to the analgesic responses induced by this compound was slower in mice lacking enkephalin. In addition, cannabinoid withdrawal syndrome, precipitated in Delta9-tetrahydrocannabinol-dependent mice by the injection of SR141716A, was significantly attenuated in mutant mice. These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence.
Abstract:	This work was supported by European Commission Grant BIOM ED-2/98–2227 and Fondo de Investigaciones Sanitaria Grant 99/0624 (R.M.), Dr. Esteve S.A. Laboratories, and La Fondation des Treilles, and by a grant from the Land Nordrhein-Westfalen (Innovationsprogramm Forschung) (A.Z.).
Matèries:	-Cannabinoides -- Efectes fisiològics -Cannabinoides -- Receptors -Drogoaddicció -- Aspectes moleculars -Cannabinoid -Opioid -Mice -Mutation -Withdrawal -Addiction -Tolerance
Drets:	(c) 2000, Society for Neuroscience. The published version is available at: http://www.jneurosci.org/content/20/24/9284
Tipus de document:	Article Article - Versió publicada
Publicat per:	Society for Neuroscience
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