To access the full text documents, please follow this link: http://hdl.handle.net/2117/19763

Title:	Calcium phosphate cements loaded with basic fibroblast growth factor: Delivery and in vitro cell response
Author:	Perez, Roman; Kim, Tae-Hyun; Kim, Meeju; Jang, Jun-Hyeog; Ginebra Molins, Maria Pau; Kim, Hae-Won
Other authors:	Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits; Centro de Investigación Biomédica en Red. Bioingeniería, Biomateriales y Nanomedicina; Tan'guk Taehakkyo
Abstract:	biological responses, especially in terms of cell proliferation. Here, we used basic fibroblast growth factor (bFGF) in an -tricalcium phosphate cement with different initial powder sizes (coarse vs. fine; designated as CPC-C and CPC-F, respectively) and investigated the behavior of bFGF loading and release, as well as the effects on osteoblast responses. bFGF was loaded at 10 g/ml or 25 g/ml onto the set form of two types of CPCs, aiming to allow penetration into the pore structure and adsorption onto the cement crystallites. The CPC formulated with fine powder (CPC-F) had higher specific surface area and smaller-sized pores and retained slightly higher amounts of bFGF within the structure. The bFGF release study performed for 3 weeks showed a sustained-release profile; after an initial rapid release over approximately...
Subject(s):	-Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials -Biomaterials -calcium phosphate cements -powder size -growth factor delivery -cell proliferation -bone regeneration -Biomaterials
Rights:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Document type:	Article - Published version Article
Share:

Show full item record