Title:
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Synthesis and antitumor activity of mechercharmycin A analogues
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Author:
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Hernández, Delia; Altuna, Marta; Cuevas, Carmen; Aligué i Alemany, Rosa Maria; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes
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Other authors:
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Universitat de Barcelona |
Abstract:
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Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide 1 and the most active derivatives, 2 and 3c, were chosen for further studies like effects on cell cycle progression and induction of apoptosis. Interestingly, the inhibition of cell division and activation of a programmed cell death by apoptosis was detected. |
Subject(s):
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-Compostos heterocíclics -Medicaments antineoplàstics -Síntesi de pèptids -Espectroscòpia de ressonància magnètica nuclear -Heterocyclic compounds -Antineoplastic agents -Peptide synthesis -Nuclear magnetic resonance spectroscopy |
Rights:
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(c) American Chemical Society , 2008
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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