Title:
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Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's Disease
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Author:
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Bosch, N.; Pugliese, Marco; Gimeno-Bayon, Javier; Rodríguez Allué, Manuel José; Mahy Gehenne, Josette Nicole
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Other authors:
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Universitat de Barcelona |
Abstract:
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In the search for appropriate models for Alzheimer's disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping to elucidate the cascade of events that take place in brain amyloid-beta (Aβ)deposition aging, and cognitive deficit. Recent innovative research has validated human methods and tools for the analysis of canine neuropathology and has allowed the development of two different approaches to investigate dogs as natural models of AD. The first approach relates AD-like neuropathy with the decline in memory and learning ability in aged housed dogs in a highly controlled laboratory environment. The second approach involves research in family-owned animals with cognitive dysfunction syndrome. In this review, we compare the strengths and limitations of housed and family-owned canine models, and appraise their usefulness for deciphering the early mechanisms of AD and developing innovative therapies. |
Subject(s):
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-Malaltia d'Alzheimer -Models animals en la investigació -Gos -Alzheimer's disease -Animal models in research -Dog |
Rights:
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(c) Bentham Science Publishers, 2012
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Document type:
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Article Article - Accepted version |
Published by:
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Bentham Science Publishers
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