Title:
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Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences
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Author:
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Cárdenas Domínguez, Martha Ivón; Vellido Alcacena, Alfredo; Giraldo Arjonilla, Jesús
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Ciències de la Computació; Universitat Politècnica de Catalunya. SOCO - Soft Computing |
Abstract:
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This brief paper addresses the problem of visually assessing the natural discriminability of the different subtypes that characterize class C G-Protein-Coupled Receptors, which are membrane proteins of interest in pharmacology, from diverse transformations of their primary amino acid sequences. Visualization, achieved using nonlinear dimensionality reduction techniques, is used as an exploratory tool to increase the interpretability of the data subtype structure. Combined with a quantitative estimation of subtype overlapping, this approach should be of help to experts in proteomics. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica -Proteomics -Bioinformatics -Amino acids -Biological membranes -Molecular biology -Proteins -G protein coupled receptors -Membrane proteins -Nonlinear dimensionality reduction -Nonlinear mappings -Primary amino acid -Primary sequences -Quantitative estimation -Visual interpretation -Data visualization -Proteòmica -Bioinformàtica |
Rights:
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Document type:
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Article - Published version Conference Object |
Published by:
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Institute of Electrical and Electronics Engineers (IEEE)
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