Progressive population aging is associated with negative social and economic impacts mainly due to its associated comorbidity rather than to aging per se. In this regard, information and communication technology resources may provide useful tools to assist the population with comorbidities through the use of telemedicine systems. However, despite their potential, such systems have not yet been effectively implemented due to a number of different reasons: absence of a clear business plan, poor acknowledgement of their clinical usefulness, and ethical and legal issues, among others. An analysis of current scenario from the point of view of the different actors (patients, health care providers, and health care systems) aimed at identifying the needs to be covered by telemedicine systems that could contribute to overcoming such problems. The present chapter is intended to offer such an analysis