Title:
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Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers
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Author:
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Puig Pitarch, Carmen; Martí Martí, Sara; Fleites, Ana; Trabazo, Rafael; Calatayud, Laura; Liñares Louzao, Josefina; Ardanuy Tisaire, María Carmen
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Abstract:
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Haemophilus influenzae colonizes the upper respiratory tract and can spread causing otitis and sinusitis. This work aimed to study the oropharyngeal carriage rate in healthy <5-year-old children attending day care centers in Oviedo, Spain in two consecutive years (January to March 2004-2005). The carriage rate was 42% (400/960) and highly variable among centers (range, 12% to 83%). Isolates were mainly identified as nontypeable H. influenzae (NTHi, 99%). Epidemiologically, 127 different genotypes were identified by PFGE with a minimum of two genotypes per center. One hundred fourteen children (12%) were included in both studies and none of them harbored the same strain over a period of time. The isolates only showed resistance to cotrimoxazol and ampicillin, presenting a shift in the level of ampicillin reduced susceptibility, showing a predominance of PBP3 mutations in 2004 and a predominance of β-lactamase production in 2005. This study proved the great genetic variability of NTHi isolates that present similar genotypic patterns in both years with no long-term carriage of the same strain. |
Subject(s):
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-Infeccions en els infants -Malalties dels infants -Bacils -Faringe -Escoles bressol -Infection in children -Children's diseases -Bacillus (Bacteria) -Pharynx -Kindergarten |
Rights:
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(c) Mary Ann Liebert, Inc., 2014
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Document type:
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Article Article - Published version |
Published by:
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Mary Ann Liebert, Inc.
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