Título:
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Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells
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Autor/a:
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Hernadez-Hernandez, Gonzalo; Álvarez Lacalle, Enrique; Shiferaw, Yohannes
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Otros autores:
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Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos |
Abstract:
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Spontaneous calcium release (SCR) occurs when ion channel fluctuations lead to the nucleation of calcium
waves in cardiac cells. This phenomenon is important since it has been implicated as a cause of various cardiac
arrhythmias. However, to date, it is not understood what determines the timing and location of spontaneous
calcium waves within cells. Here, we analyze a simplified model of SCR in which calcium release is modeled as
a stochastic processes on a two-dimensional network of randomly distributed sites. Using this model we identify
the essential parameters describing the system and compute the phase diagram. In particular, we identify a critical
line which separates pinned and propagating fronts, and show that above this line wave nucleation is governed by
fluctuations and the spatial connectivity of calcium release units. Using a mean-field analysis we show that the
sites of wave nucleation are predicted by localized eigenvectors of a matrix representing the network connectivity
of release sites. This result provides insight on the interplay between connectivity and fluctuations in the genesis
of SCR in cardiac myocytes |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria biomèdica -Calcium ions -Arrhythmias, Cardiac--physiopathology -Arrítmia |
Derechos:
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http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo - Versión publicada Artículo |
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