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Título:	Molecular characterization of Streptococcus pneumoniae invasive serotype 19A isolates from adults in two Spanish regions (1994-2009)
Autor/a:	Marimón, José María; Alonso, Marta; Rolo, D.; Ardanuy Tisaire, María Carmen; Liñares Louzao, Josefina; Pérez Trallero, Emilio
Otros autores:	Universitat de Barcelona
Abstract:	From 1994 to 2009, the incidence of invasive serotype 19A pneumococci isolated from adults in Barcelona and San Sebastian almost doubled every 4 years. Genotyping of the 167 invasive isolates studied showed serotype 19A to be highly heterogeneous, with 35 different sequence types (STs) and a different clonal structure in each region and time period. Multiresistance, defined as non-susceptibility to three or more antimicrobials, was found in 86 (51.5%) isolates. The most frequent ST was the multidrug-resistant ST276 (n = 28), which is a single-locus variant of the Denmark14-ST230 global clone. The ST276 clone, only present in San Sebastian before 2001, was successfully disseminated from 2002 in both cities and was the main contributor to the overall increase of serotype 19A infections.
Materia(s):	-Estreptococs -Pneumococs -Infeccions per pneumococs -Vacuna antipneumocòccica -Resistència als medicaments -Barcelona (Catalunya : Província) -Sant Sebastià (País Basc) -Espanya -Streptococcus -Streptococcus pneumonia -Pneumococcal Infections -Pneumococcal vaccine -Drug resistance -Barcelona (Catalonia : Province) -San Sebastián (Basque Country) -Spain
Derechos:	(c) Springer Verlag, 2012
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	Springer Verlag
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