Título:
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Childhood adversity and psychosis: examinig whether the association is due to genetic confounding using a monozygotic twin differences approach
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Autor/a:
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Alemany Sierra, Silvia; Goldberg, Ximena; Van Winkel, R.; Gastó Ferrer, Cristóbal; Peralta, V.; Fañanás Saura, Lourdes
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Otros autores:
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Universitat de Barcelona |
Abstract:
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Purpose: To test whether the association between childhood adversity and positive and negative psychotic experiences is due to genetic confounding. Method: Childhood adversity and psychotic experiences were assessed in a sample of 226 twins from the general population. A monozygotic (MZ) twin differences approach was used to assess possible genetic confounding. Results: In the whole sample, childhood adversity was significantly associated with positive (β =.45; SE=.16; p=.008) and negative psychotic experiences (β=.77; SE=.18; p<.01). Within-pair MZ twin differences in exposure to childhood adversity were significantly associated with differences in positive (β =.71; SE=.29; p=.016) and negative psychotic experiences (β =.98; SE=.38; p=.014) in a subsample of 86 MZ twin pairs. Conclusions: Individuals exposed to childhood adversity are more likely to report psychotic experiences. Furthermore, our findings indicate that unique environmental effects of childhood adversity contribute to the development of psychotic experiences. |
Materia(s):
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-Genètica -Psicopatologia infantil -Esquizofrènia -Infants maltractats -Genetics -Child psychopathology -Schizophrenia -Abused children |
Derechos:
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(c) Elsevier Masson SAS, 2013
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier Masson SAS
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Compartir:
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