Autor/a:
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Bosch Hereu, Lluís; Cialîcu, Ionela; Caner, Joaquim; Ariza Piquer, Xavier; Costa i Arnau, Anna M.; Terrazas Martínez, Montserrat; Vilarrasa i Llorens, Jaume
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Abstract:
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Pd-catalysed reactions of 2-Cl, 2-Br and 2-I derivatives of a 6-chloropurine nucleoside with benzamide have been compared, using Pd2dba3, Xantphos and Cs2CO3 in toluene, between 20 and 80 °C. The reactivity order was 2-I > 2-Br > 6-Cl ≫ 2-Cl. The 2-I substituent could be replaced even at 0 °C, under conditions disclosed here for the first time. On the other hand, the replacement of the chlorine atom at position 2 (2-Cl) required 110 °C. |