Title:
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An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies
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Author:
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Gandioso, Albert; Shaili, Evyenia; Massaguer i Vall-llovera, Anna; Artigas Solé, Gerard; González-Cantó, Alejandro; Woods, Julie A.; Sadler, Peter; Marchán Sancho, Vicente
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Other authors:
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Universitat de Barcelona |
Abstract:
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A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing alphaVbeta3 integrin compared to control DU-145 human prostate carcinoma cells. |
Subject(s):
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-Quimioteràpia del càncer -Cancer chemotherapy |
Rights:
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(c) Gandioso, Albert et al., 2015
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Document type:
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Article Article - Accepted version |
Published by:
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Royal Society of Chemistry
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