Title:
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Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology
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Author:
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Lloberas Cavero, Jorge; Valverde Estrella, Lorena; Tur, Juan; Vico, Tania; Celada Cotarelo, Antonio
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Other authors:
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Universitat de Barcelona |
Abstract:
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Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation. |
Subject(s):
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-Enzims -Macròfags -Esterases -Enzymes -Macrophages -Esterases |
Rights:
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cc-by (c) Lloberas et al., 2016
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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Frontiers Media
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