Title:
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Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands
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Author:
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Salomó, Ernest; Orgué Gassol, Sílvia; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier
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Other authors:
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Universitat de Barcelona |
Abstract:
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A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*. |
Subject(s):
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-Compostos fosforosos -Lligands (Bioquímica) -Phosphorus compounds -Ligands (Biochemistry) |
Rights:
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(c) Georg Thieme Verlag, 2016
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Document type:
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Article Article - Accepted version |
Published by:
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Georg Thieme Verlag
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