Title:
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Reentry produced by small-scale heterogeneities in a discrete model of cardiac tissue
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Author:
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Alonso Muñoz, Sergio; Bär, Markus
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos |
Abstract:
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Reentries are reexcitations of cardiac tissue after the passing of an excitation wave which can cause
dangerous arrhythmias like tachycardia or life-threatening heart failures like fibrillation. The heart is formed by a
network of cells connected by gap junctions. Under ischemic conditions some of the cells lose their connections,
because gap junctions are blocked and the excitability is decreased. We model a circular region of the tissue where
a fraction of connections among individual cells are removed and substituted by non-conducting material in a twodimensional
(2D) discrete model of a heterogeneous excitable medium with local kinetics based on electrophysiology.
Thus, two neighbouring cells are connected (disconnected) with a probability f (1 - f). Such a region is assumed to be
surrounded by homogeneous tissue. The circular heterogeneous area is shown to act as a source of new waves which
reenter into the tissue and reexcitate the whole domain. We employ the Fenton-Karma equations to model the action potential for the local kinetics of the discrete nodes to study the statistics of the reentries in two dimensional networks
with different topologies. We conclude that the probability of reentry is determined by the proximity of the fraction of
disrupted connections between neighboring nodes ( |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències -Biomathematics -Cells -Cytology -Electrophysiology -Heart -Hysteresis -Quantum theory -Reentry -Solvents -Topology -Conducting materials -Heterogeneous region -Homogeneous tissues -Ischemic conditions -Percolation thresholds -Small-scale heterogeneity -Two Dimensional (2 D) -Two-dimensional networks -Biomatemàtica |
Rights:
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http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Published version Conference Object |
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