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Title:
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Sarcomere disruptions of slow fibres resulting from mountain ultramarathon;
Mountain ultramarathon and sarcomere disruptions of slow fibers
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Author:
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Carmona, Gerard; Roca, Emma; Guerrero, Mario; Cussó, Roser; Irurtia Amigo, Alfredo; Nescolarde Selva, Lexa Digna; Brotons, Daniel; Bedini, José Luis; Cadefau, Joan
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. IEB - Instrumentació Electrònica i Biomèdica |
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Abstract:
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Objective: To investigate changes after a mountain ultramarathon (MUM) in the serum concentration of fast (FM) and slow (SM) myosin isoforms, which are fiber-type-specific sarcomere proteins. The changes were compared against creatine kinase (CK), a widely used fiber-sarcolemma-damage biomarker, and cardiac troponin I (cTnI), a widely used cardiac biomarker. Methods: Observational comparison of response in a single group of 8 endurance-trained amateur athletes. Time-related changes in serum levels of CK, cTnI, SM, and FM from competitors were analyzed before, 1 h after the MUM, and 24 and 48 h after the start of the MUM by 1-way ANOVA for repeated measures or Friedman and Wilcoxon tests. Pearson correlation coefficient was employed to examine associations between variables. Results: While SM was significantly (P = .009) increased in serum 24 h after the beginning of the MUM, FM and cTnI did not change significantly. Serum CK activity peak was observed 1 h after the MUM (P = .002). Moreover, serum peaks of CK and SM were highly correlated (r = .884, P = .004). Conclusions: Since there is evidence of muscle damage after prolonged mountain running, the increase in SM serum concentration after a MUM could be indirect evidence of slow- (type I) fiber-specific sarcomere disruptions. |
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Abstract:
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Peer Reviewed |
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Subject(s):
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-Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana
-Sports injuries
-Muscles
-Racing
-Runners (Sports)
-Creatine kinase
-Músculs
-Esports--Lesions
-Curses
-Corredors (Esports)
-Creatina quinasa |
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Rights:
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Document type:
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Article - Published version
Article |
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