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Título:	Opposite cannabis-cognition associations in psychotic patients depending on family history
Autor/a:	González-Pinto, Ana; González Ortega, Itxaso; Alberich, Susana; Ruiz de Azúa, Sonia; Bernardo Arroyo, Miquel; Bioque Alcázar, Miquel; Cabrera, Bibiana; Corripio, Iluminada; Arango, Celso; Lobo, Antonio; Sánchez-Torres, Ana M.; Cuesta, Manuel J.; PEPS Group
Otros autores:	Universitat de Barcelona
Abstract:	The objective of this study is to investigate cognitive performance in a first-episode psycho- sis sample, when stratifying the interaction by cannabis use and familial or non-familial psy- chosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family his- tory of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no fam- ily history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis
Materia(s):	-Cànnabis -Psicosi -Malalties hereditàries -Memòria -Cognició -Neuropsicologia clínica -Cannabis -Psychoses -Genetic diseases -Memory -Cognition -Clinical neuropsychology
Derechos:	cc-by (c) González Pinto, Ana et al., 2016 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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