Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.

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RECERCAT Home > Universitat de Barcelona > Biomedicina > Articles publicats en revistes (Biomedicina) > View document

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Title:	Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.
Author:	Delgado, Julio (Delgado González); Bielig, Torsten; Bonet, Lizette; Carnero-Montoro, Elena; Puente, Xose S.; Colomer Pujol, Dolors; Bosch, Elena; Campo Güerri, Elias; Lozano Soto, Francisco
Other authors:	Universitat de Barcelona
Abstract:	Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis.
Subject(s):	-Leucèmia limfocítica crònica -Receptors cel·lulars -Cèl·lules B -Biologia molecular -Immunologia -Chronic lymphocytic leukemia -Cell receptors -B cells -Molecular biology -Immunology
Rights:	(c) John Wiley & Sons Ltd, 2016
Document type:	Article Article - Submitted version
Published by:	Blackwell Science
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