Título:
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A General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines
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Autor/a:
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Amat Tusón, Mercedes; Fabregat, Robert; Griera Farres, Rosa; Bosch Cartes, Joan
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Otros autores:
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Universitat de Barcelona |
Abstract:
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A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring. |
Materia(s):
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-Quinolones -Síntesi orgànica -Lactames -Reacció d'oxidació-reducció -Quinolone antibacterial agents -Organic synthesis -Lactams -Oxidation-reduction reaction |
Derechos:
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(c) American Chemical Society , 2009
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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American Chemical Society
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