Title:
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Asymmetric intermolecular cobalt-catalyzed Pauson-Khand reaction using a p-stereogenic bis-phosphane
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Author:
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Orgué Gassol, Sílvia; Leon, Thierry; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier
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Other authors:
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Universitat de Barcelona |
Abstract:
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The asymmetric intermolecular and catalytic Pauson-Khand reaction has remained an elusive goal since Khand and Pauson discovered this transformation. Using a novel family of P-stereogenic phosphanes, we developed the first catalytic system with useful levels of enantioselection for the reaction of norbornadiene and trimethylsilylacetylene. The results demonstrate that Co-bisphosphane systems are sufficiently reactive and that they lead to high selectivity in the intermolecular process. |
Subject(s):
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-Reacció de Pauson-Khand -Catàlisi asimètrica -Pauson-Khand reaction -Enantioselective catalysis |
Rights:
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(c) American Chemical Society , 2014
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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