Title:
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Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics
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Author:
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Farzam, Parisa; Johansson, Johannes; Mireles, Miguel; Jiménez-Valerio, Gabriela; Martínez-Lozano, Mar; Choe, Regine; Casanovas, Oriol; Durduran, Turgut
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Other authors:
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Universitat Politècnica de Catalunya. Institut de Ciències Fotòniques |
Abstract:
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The longitudinal effect of an anti-vascular endothelial growth factor receptor 2
(VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse
model was monitored using hybrid diffuse optics. Two groups of immunosuppressed male nude
mice (seven treated, seven controls) were measured. Tumor microvascular blood flow, total
hemoglobin concentration and blood oxygenation were investigated as potential biomarkers for the
monitoring of the effect of therapy twice a week and were related to the final treatment outcome.
These hemodynamic biomarkers have shown a clear differentiation between two groups by day
four. Moreover, we have observed that pre-treatment values and early changes in hemodynamics
are highly correlated with the therapeutic outcome demonstrating the potential of diffuse optics
to predict the therapy response at an early time point. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Física -spectroscopy -Spectroscopy -Òptica |
Rights:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Document type:
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Article - Published version Article |
Published by:
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OSA
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