Title:
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Continuous determination of blood glucose in children admitted
with malaria in a rural hospital in Mozambique
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Author:
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Madrid, Lola; Sitoe, Antonio; Varo, Rosauro; Nhampossa, Tacilta; Lanaspa, Miguel; Nhama, Abel; Acácio, Sozinho; Riaño, Isolina; Casellas, Aina; Bassat Orellana, Quique
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Abstract:
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BACKGROUND: Hypoglycaemia is a frequent complication among
admitted children, particularly in malaria-endemic areas. This
study aimed to estimate the occurrence of hypoglycaemia not only
upon admission but throughout the first 72 h of hospitalization
in children admitted with malaria. METHODS: A simple pilot study
to continuously monitor glycaemia in children aged 0-10 years,
admitted with malaria in a rural hospital was conducted in
Southern Mozambique by inserting continuous glucose monitors
(CGMs) in subcutaneous tissue of the abdominal area, producing
glycaemia readings every 5 min. RESULTS: Glucose was
continuously monitored during a mean of 48 h, in 74 children.
Continuous measurements of blood glucose were available for
72/74 children (97.3%). Sixty-five of them were admitted with
density-specific malaria diagnosis criteria (17 severe, 48
uncomplicated). Five children (7.7%) had hypoglycaemia (<54
mg/dL) on admission as detected by routine capillary
determination. Analysing the data collected by the CGMs,
hypoglycaemia episodes (<54 mg/dL) were detected in 10/65
(15.4%) of the children, of which 7 (10.8%) could be classified
as severe (=45 mg/dL). No risk factors were independently
associated with the presence of at least one episode of
hypoglycaemia (<54 mg/dL) during hospitalization. Only one
death occurred among a normoglycaemic child. All episodes of
hypoglycaemia detected by CGMs were subclinical episodes or not
perceived by caregivers or clinical staff. CONCLUSIONS:
Hypoglycaemia beyond admission in children with malaria appears
to be much more frequent than what had been previously
described. The clinical relevance of these episodes of
hypoglycaemia in the medium or long term remains to be
determined. |
Subject(s):
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-Malària -Moçambic -Glucosa -Malaria -Mozambique -Glucose |
Rights:
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cc by (c) Madrid et al., 2017
http://creativecommons.org/licenses/by/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Biomed Central
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