Title:
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Enantioselective total synthesis of fluvirucinin B1
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Author:
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Guignard, Guillaume; Llor Brunés, Núria; Molins i Grau, Elies; Bosch Cartes, Joan; Amat Tusón, Mercedes
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Other authors:
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Universitat de Barcelona |
Abstract:
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A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed. |
Subject(s):
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-Síntesi orgànica -Lactames -Organic synthesis -Lactams |
Rights:
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(c) American Chemical Society , 2016
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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