Títol:
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Incidental mosquitocidal effect of an ivermectin mass drug
administration on Anopheles farauti conducted for scabies
control in the Solomon Islands
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Autor/a:
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Kositz, Christian; Talina, Jeptah; Diau, Jason; Asugeni, Rowena; Whitehorn, Cheryl; Mabey, David C. W.; Chaccour, Carlos; Marks, Michael
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Abstract:
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Background: The Solomon Islands is targeting elimination of
malaria by 2030. The dominant vector is the predominantly
exophagic, exophilic Anopheles farauti sensu strictu. This
biting behaviour limits the efficacy of conventional vector
control tools and highlights the need for new strategies. When
administered to humans ivermectin has been shown to have a
mosquitocidal effect. Mass drug administration (MDA) with
ivermectin is an emerging strategy in the control of scabies. In
this study we explored any incidental effect of ivermectin MDA
conducted for scabies control on mosquitoes. Methods: MDA for
scabies was conducted in three villages. We performed human
landing catches and measured 5-day mortality amongst Anopheles
mosquitoes caught before and after MDA. Cox regression was used
to calculate hazard ratios (HR) for mortality between mosquitoes
caught before and after MDA. Results: There was a significant
increase in 5-day mortality in anopheline mosquitoes caught
post-MDA which was highest on the day of MDA itself (HR 4.2 95%
CI 1.8 to 10.1, p=0.001) and the following day (HR 4.4 95% CI
1.8 to 10.8, p=0.002) compared to mosquitoes caught before MDA.
Conclusions: This study shows a possible mosquitocidal effect of
ivermectin MDA conducted for scabies control. Studies with a
larger sample size with clinical as well as entomological
outcomes should be conducted in this population. |
Matèries:
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-Malària -Medicina tropical -Salomó -Malaria -Tropical medicine -Solomon Islands |
Drets:
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cc by (c) Kositz et al., 2017
http://creativecommons.org/licenses/by/4.0/ |
Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Oxford University Press
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