Author:
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Serrano, Aurora; Carmona, F. David; Castañeda, Santos; Solans, Roser; Hernández Rodríguez, José; Cid Xutglà, M. Cinta; Prieto González, Sergio; Miranda-Filloy, José A.; Rodríguez-Rodríguez, Luis; Morado, Inmaculada C.; Gómez Vaquero, Carmen; Blanco, Ricardo; Sopeña, Bernardo; Ortego Centeno, Norberto; Unzurrunzaga, Ainhoa; Marí-Alfonso, Begoña; Sánchez-Martin, Julio; García-Villanueva, María Jesús; Hidalgo-Conde, Ana; Pazzola, Giulia; Boiardi, Luigi; Salvarani, Carlo; González-Gay, Miguel A.; Martín, Javier
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Abstract:
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Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation. |