Title:
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Chitosan patterning on titanium alloys
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Author:
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Gilabert Chirivella, Eduardo; Pérez Feito, Ricardo; Ribeiro, Clarisse; Ribeiro, Sylvie; Correia, Daniela; González Martin, María Luisa; Manero Planella, José María; Lanceros Méndez, Senentxu; Gallego Ferrer, Gloria; Gómez Ribelles, José Luis
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica; Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits; Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular |
Abstract:
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Titanium and its alloys are widely used in medical implants because of their excellent properties. However,
bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration.
In this study, we report a new simple method of providing titanium surfaces with antibacterial properties by
alternating antibacterial chitosan domains with titanium domains in the micrometric scale. Surface microgrooves
were etched on pure titanium disks at intervals of 60 μm using a modified 3D printer and were then
coated with chitosan antibacterial polysaccharide. The dimensions of the patterned microgrooves made it
possible to fix the chitosan domains to the titanium substrate without the need for covalent bonding. These
domains were stable after 5 days of immersion in water and reduced the surface contact angle. Preliminary cell
adhesion assays demonstrated that MC3T3-E1 pre-osteoblasts preferentially adhered to the titanium regions,
while C2C12 myoblasts were uniformly distributed over the whole surface. |
Abstract:
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Peer Reviewed |
Subject(s):
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-Àrees temàtiques de la UPC::Enginyeria biomèdica -Titanium -Chitosan -Myoblasts -Cell adhesion -Titani |
Rights:
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Document type:
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Article - Submitted version Article |
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