Títol:
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High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides
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Autor/a:
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Gamba, Ilaria; Salvadó, Iria; Brissos, Rosa F.; Gámez Enamorado, Patrick; Brea, José; Loza, María Isabel; Vázquez, M. Eugenio; Vázquez López, Miguel
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Altres autors:
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Universitat de Barcelona |
Abstract:
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We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines. |
Matèries:
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-Síntesi de pèptids -Física de l'estat sòlid -ADN -Càncer -Peptide synthesis -Solid state physics -DNA -Cancer |
Drets:
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(c) Gamba, Ilaria et al., 2016
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Tipus de document:
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Article Article - Versió acceptada |
Publicat per:
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Royal Society of Chemistry
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Compartir:
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