The purpose of this study was to conduct a meta-analysis on the effects of neuropsychological rehabilitation procedures on the quality of life in non-Spanish-speaking individuals with some cognitive deficit. Sixteen studies published during the 2001-2012 period which yielded relevant information regarding the sample sizes used, the types of statistical contrasts, the evaluation instruments or pathologies among others, were analyzed. We carried out study following the usual estimation procedures, based on the definition of the effect size and the scrutiny of their relationship with relevant variables (e.g., sample sizes, type of population), or methodological variables (e.g., type of research or sampling design). The data analysis shows a statistically significant effect ( r + = .38; p < .001) in all the variables associated with the characteristics of the intervention (duration, type of intervention, gender, year of publication and, more importantly, quality of life and neuropsychological outcomes). As a general conclusion, we were able to determine that Quality of Life (QoL) can improve, under certain conditions, through neuropsychological rehabilitation, but this change is not permanent.