A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis

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Título:	A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis
Autor/a:	Muñoz Pinedo, Cristina; López Rivas, Abelardo
Abstract:	Glab and colleagues examine in a recent paper apoptosis induced by some driverss of endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published report2 , DR5/TRAIL-R2 and caspase-8 are universally dispensable in ER stress-induced apoptosis. We argue here that their own data and other published reports indicate that in many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the unfolded protein response (UPR), upon chronic ER stress.
Materia(s):	-Proteïnes -Apoptosi -Proteins -Apoptosis
Derechos:	(c) Cell Death & Differentiation, 2017
Tipo de documento:	Otros Artículo - Versión aceptada
Editor:	Nature Publishing Group
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Cano-González, Ana; Mauro-Lizcano, Marta; Iglesias i Serret, Daniel; Gil i Santano, Joan; López Rivas, Abelardo

Püschel, Franziska; Muñoz Pinedo, Cristina

Pfeiffer, S.; Anilkumar, U.; Chen, G.; Ramírez Peinado, Silvia; Galindo Moreno, Javier; Muñoz Pinedo, Cristina; Prehn, J. M. H.

Muñoz Pinedo, Cristina; Martin, S. J.

Galindo Moreno, Javier; Iurlaro, Raffaella; Mjiyad, Nadia El; Díez Pérez, J.; Gabaldón, T.; Muñoz Pinedo, Cristina

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