Título:
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Treatment of Chronic Hepatitis C in HIV-Infected Patients with Interferon α-2b Plus Ribavirin
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Autor/a:
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Pérez-Olmeda, Mayte; Soriano, Vincent; Asensi, Victor; Morales, Dolores; Romero, Miriam; Ochoa, Anna; Sánchez-Montero, Fausto; Santín Cerezales, Miguel; Guardiola, Josep; Blanch, Jesús; Núñez, Marina; Jiménez-Nácher, Inmaculada; García-Samaniego, Javier; HCV/HIV Spanish Study Team
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Otros autores:
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Universitat de Barcelona |
Abstract:
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One hundred six HIV-infected patients with chronic hepatitis C virus (HCV) infection were randomized to receive ribavirin (RBV) 400 mg bid plus interferon α-2b (IFN-α) at two different doses, 3 mU tiw (control arm) or 5 mU daily for the first 6 weeks, followed by 3 mU tiw until completing 6 months of therapy (induction arm). All patients had CD4 counts above 350 cells/μl and 89% were taking antiretroviral therapy. Adverse effects leading to treatment discontinuation occurred in 12.3% of patients, a rate quite similar to that seen in HCV-monoinfected patients. Negative serum HCV-RNA values (<60 IU/ml) were recorded in 24.7% and 35.5% of patients at 3 and 6 months of therapy. However, in the intent-to-treat analysis, sustained response was reached by only 16% of patients (22.4% in the on-treatment analysis). No differences between treatment arms were noticed. Patients with HCV genotypes 2 or 3 had a 7-fold higher response rate than those with HCV genotypes 1 or 4. Therefore, early, end-of-treatment, and sustained response rates are lower in HIV/HCV-coinfected patients treated with RBV/IFN-α combination therapy. Since HCV-related liver disease is currently one of the leading causes of morbidity and mortality among HIV-infected patients, new treatment options are urgently needed for coinfected individuals. |
Materia(s):
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-Hepatitis C -Interferó -Efecte dels medicaments sobre els microorganismes -Medicaments antivírics -Infeccions per VIH -Hepatitis C -Interferon -Effect of drugs on microorganisms -Antiviral agents -HIV infections |
Derechos:
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(c) Mary Ann Liebert, 2003
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Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Mary Ann Liebert
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Compartir:
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