Títol:
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Deep white matter in Huntington's disease
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Autor/a:
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Phillips, Owen; Squitieri, Ferdinando; Sánchez Castañeda, Cristina; Elifani, Francesca; Caltagirone, Carlo; Sabatini, Umberto; Paola, Margherita di
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Altres autors:
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Universitat de Barcelona |
Abstract:
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White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed increased axial (AD) and radial diffusivity (RD) and iron levels in Pre-HD subjects compared to controls. Fractional anisotropy decreased between the Pre-HD and HD phase and AD/RD increased and although impairment was pervasive in HD, degeneration occurred in a pattern in Pre-HD. Furthermore, iron levels dropped for HD patients. As increased iron levels are associated with remyelination, the data suggests that Pre-HD subjects attempt to repair damaged deep WM years before symptoms occur but this process fails with disease progression. |
Matèries:
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-Demència -Corea de Huntington -Malalties neurodegeneratives -Dementia -Huntington's chorea -Neurodegenerative diseases |
Drets:
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cc-by (c) Phillips, Owen et al., 2014
http://creativecommons.org/licenses/by/3.0/es |
Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Public Library of Science (PLoS)
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