Keplerates are a family of anionic metal oxide spherical capsules containing up to 132 metal atoms and some hundreds of oxygens. These capsules holding a high negative charge of -12 coordinate both mono-anionic and di-anionic ligands thus raising its charge till -42 even till -72, which is compensated by the corresponding counter-cations in X-Ray structures. We present an analysis of the relative importance of several energy terms of the coordinate bond between the capsule and ligands like carbonate, sulphate, sulphite, phosphinate, selenate, and a variety of carboxylates, of which the overriding component is the contribution due to solvation/de-solvation effects.